Publications (2016 onwards)

  1. James T, Rahiman K.M. M, Sebastian D, Rani S S, M.D D and Prakasam Thanka P (2026) Effect of IgY antibody coated fish feed in preventing motile Aeromonas septicaemia in Ctenopharyngodon idella: a histopathological perspective. Front. Immunol. 17:1885532. (IF: 7) https://doi.org/10.3389/fimmu.2026.1885532

  2. Renu Indhikkattu Chittoor, Denoj Sebastian, Harikumaran Thampi Balakrishnan Saraswathi. Innovations In in Silico Assessment of Quercetin: Anti-Inflammatory Perspectives. Int. J. of Pharm. Sci., 2026, Vol. 4, Issue 5, 5257–5277. https://doi.org/10.5281/zenodo.20309501

  3. Pooja Sankaranarayanan, J. Parvathy, Aarya Sreedevi, Denoj Sebastian & Suchithra Tharamel Vasu. In vitro and in silico validation of the therapeutic potential of Tea tree (Melaleuca alternifolia) oil through GC/MS integrated profiling, and molecular dynamic simulation. In Silico Pharmacol. 14, 105 (2026). (IF: 2.5). https://doi.org/10.1007/s40203-026-00610-x

  4. Skariyachan, S., Nair, A.G.S., Sebastian, D. et al. Integrative AI and Molecular Simulation Reveal Andrograpanin as a Potent Dual Inhibitor of EYA1 and TFAP2A in Triple-Negative Breast Cancer. J Pharm Innov 21, 511 (2026). (IF: 3). https://doi.org/10.1007/s12247-026-10731-7

  5. Skariyachan, S., Mathamangalath, G. K., Sebastian, D., & Sreejith, K. Molecular docking and dynamics simulations identify marine sponge–derived Halenaquinone as a promising STAT4 modulator for rheumatic heart disease. SAR and QSAR in Environmental Research, (2026), 1–26. (IF: 2.4). https://doi.org/10.1080/1062936X.2026.2631015

  6. Smitha Chacko, Emmanuel Simon, Denoj Sebastian. Bioprocess optimization of L-glutaminase production by a novel Klebsiella pneumoniae strain SCPRC using response surface methodology. Preparative Biochemistry and Biotechnology (2026). (IF: 1.9). https://doi.org/10.1080/10826068.2025.2607434

  7. Skariyachan, S., Niranjan, V., Setlur, A. S., Vijayan, S., & Sebastian, D. Integrative computational approaches in the quest for novel Ebolavirus therapeutics. Expert Opinion on Drug Discovery, 1–15 (2026). (IF: 6.3). https://doi.org/10.1080/17460441.2025.2605348

  8. Abdul Bari K. K, Rasiya K. T, Denoj Sebastian. Correlation of biofilm-associated genes and phenotypic detection methods in multidrug-resistant clinical Escherichia coli. Indian Journal of Microbiology Research (2025); 12(4). (IF: 2.5). https://doi.org/10.18231/j.ijmr.13100.1765344808

  9. Thushara James, K.M. Mujeeb Rahiman, Denoj Sebastian, S. Suja Rani and M.D. Dinesh. In-vitro evaluation of IgY Antibodies against Aeromonas caviae and Cross-reactivity with Aeromonas hydrophila. The Microbe (2025). (IF: 1.9). https://doi.org/10.1016/j.microb.2025.100652

  10. Pooja Sankaranarayanan, Aarya Sreedevi, J. Parvathy, Denoj Sebastian, and Suchithra Tharamel Vasu. Exploring the Antimicrobial Perspective of Citronella (Cymbopogon nardus) Oil Through GC/MS-based Compound Identification, Molecular Docking, and MD Simulation Insights. Journal of Computational Biophysics and Chemistry (2025). (IF: 2.3). https://doi.org/10.1142/S2737416526500316

  11. Sinosh Skariyachan, Jyotsna Jyothindran Kelambeth, Denoj Sebastian, Naracham Veettil Vinod, Narayanappa Rajeswari. Boeravinone Derivatives from Boerhavia diffusa Potently Target GMP Synthase in Drug-Resistant Acinetobacter baumannii: An AI-Guided In Silico Approach to Combat Antimicrobial Resistance. Biochemical and Biophysical Research Communications (2025). (IF: 2.2). https://doi.org/10.1016/j.bbrc.2025.152630

  12. Sinosh Skariyachan, Swathi Vijayan, Denoj Sebastian, Vinod Naracham Veettil, Narayanappa Rajeswari, Rachana Kaitheri Edathil. Structure-based identification of dual targeting lead inhibitor to Marburg virus glycoprotein and Chandipura virus nucleoprotein: Insights from molecular docking, dynamics and binding free energy analyses. Biochemical and Biophysical Research Communications. Volume 776 (2025). (IF: 2.2). https://doi.org/10.1016/j.bbrc.2025.152239

  13. James, T., Rahiman KM, M., Sebastian, D., S, S. R., & MD, D. The combinational effect of avian IgY antibodies and broad-spectrum antibiotics (ciprofloxacin and chloramphenicol) in vitro reduces the incidence of Aeromonas hydrophila. Journal of Applied Aquaculture, 1–16 (2025). (IF: 1.3). https://doi.org/10.1080/10454438.2025.2478842

  14. Paulson, Honeymol K., Simon, Emmanuel, Radhakrishnan, Supriya and Sebastian, Denoj. Enterobacter cloacae strain isolated from wastewater, a potential candidate for formulation of bioremediation strategies. Pure and Applied Chemistry (2025). (IF: 0.9). https://doi.org/10.1515/pac-2024-0341

  15. Sunilkumar, Harishankar, Venpalackal, Haripriya R., Nair, Aswathy S., Sivasankarapillai, Rani V., Simon, Emmanuel and Radhakrishnan, Supriya. Green synthesis, characterization and bioactivity analysis of eco-friendly silver nanoparticles using Schefflera actinophylla flowers. Pure and Applied Chemistry (2025). https://doi.org/10.1515/pac-2024-0378

  16. Jowhara P. Varancheri, Seena T. Pandarekandy, Jyoti R. Chandran, Jean Maliekkal, Ajitha Balakrishnan, Sreekumaran Edakkot. Relationship of low birth weight and socioeconomic factors: a case-control study in tertiary care centre in north Kerala. International Journal of Community Medicine and Public Health (2025); 12(8): 3571.

  17. N George, D Gayathri Devi. Regulating Enzyme Catalysis by Tailored Silver Nanocrystals Fabricated with Holigarna arnottiana—Synthesis, Characterization, and Performance Optimization. Biological Trace Element Research 202 (9), 4240–4259 (2024).

  18. K Merin Rinky, D Gayathri Devi, VK Priya. Fagopyrin F fraction from Fagopyrum tataricum demonstrates photodynamic inactivation of skin infecting bacterium and squamous cell carcinoma (A431) cells. Photochemical & Photobiological Sciences, 1–19 (2024).

  19. George, N., Devi, D.G. Phytonano silver for cosmetic formulation—synthesis, characterization, and assessment of antimicrobial and antityrosinase potential. Discover Nano 19, 65 (2024). https://doi.org/10.1186/s11671-024-04008-6

  20. Nithya Jayan, Sinosh Skariyachan, Denoj Sebastian. The escalated potential of the novel isolates of Bacillus cereus NJD1 for effective biodegradation of LDPE films without pre-treatment. Journal of Hazardous Materials (2023). (IF: 14.224). https://doi.org/10.1016/j.jhazmat.2023.131623

  21. Thushara James, K.M. Mujeeb Rahiman, Denoj Sebastian, S. Suja Rani and M.D. Dinesh. Growth inhibitory properties of specific anti-A. hydrophila IgY antibodies—A promising approach for the prevention of Aeromonas infection in farmed fish. Indian Hydrobiology. 22(2): 211–220 (2023).

  22. Abhini KN, Akhila B Rajan, Fathimathu Zuhara K and Denoj Sebastian. Response surface methodological optimization of L-asparaginase production from a medicinal plant endophyte Acinetobacter baumannii ZAS1. J Genet Eng Biotechnol 20, 22 (2022). (IF: 2.93, Scopus CiteScore 5.5). https://doi.org/10.1186/s43141-022-00309-4

  23. Sneha Das, Kainoor Krishnankutty Janardhanan, & B.S. Harikumaran Thampi. Bioactive Extract of Morel Mushroom, Morchella esculenta (Ascomycota) Attenuates Doxorubicin-Induced Oxidative Stress Leading to Myocardial Injury. International Journal of Medicinal Mushrooms, 24(8):31 – 44 (2022) https://doi.org/10.1615/IntJMedMushrooms.2022044516
  24. K. P. Lijith. K. Merin Rinky. D. Gayathri Devi. Purification, characterization and antioxidant efficacy testing of trypsin inhibitor protein from Anonna squamosa seeds. Journal of Plant Biochemistry and Biotechnology. https://doi.org/10.1007/s13562-022-00789-y
  25. Chanchitha Chandran, P. Smitha & D. Gayathri Devi. Seed Protein from Artocarpus hirsutus Lam. with Trypsin Inhibitory, Microbicidal and Antioxidant Activities Induces Depletion of Human Skin Cancer (A431) and Colon Cancer (HT29) Cells. Journal of Biologically Active Products from Nature. (2022) https://doi.org/10.1080/22311866.2021.2008269
  26. Preenanka R, Denoj Sebastian. Characterization of green synthesized antibacterial silver nanoparticles from Amaranthus spinosus L. Extract. Bionanoscience. (2022) (Impact Factor: 2.305). https://doi.org/10.1007/s12668-022-00965-3
  27. Rinju R and B S Harikumaran Thampi Characteristics of Starch Extracted from the Stem of Pineapple Plant (Ananas comosus) - an Agro Waste from Pineapple Farms Brazilian Archives of Biology and Technology 2021 https://doi.org/10.1590/1678-4324-2021190276
  28. Merin Rinky K, Lijith K P, Chanchitha Chandran and Gayathri Devi D. Identification of Artocarpus hirsutus and Garcinia gummi-gutta as the sources of trypsin inhibitory proteins whose activity can be modulated by industrial additives. Indian Journal of Natural Products and Resources (IJNPR) 2021
  29. J Puthukkara, S. Renganathan, A Menon, RG Pillai, Beneficial impacts of Astaxanthine on biomarkers of antioxidant status and oxidative damage in rats exposed to ambient air,  Chem boil Letters 2021  http://thesciencein.org/cbl
  30. Liji. P, Sinosh Skariyachan and B. S. Harikumaran Thampi. Cytotoxic effects of butyric acid derivatives through GPR109A receptor in Colorectal Carcinoma cells by in silico and in vitro methods Journal of Molecular Structure 2021  https://doi.org/10.1016/j.molstruc.2021.130832
  31. N. S. Rajendran and B.S. Harikumaran Thampi. Extraction, rheological and textural analyses and grading of pectin from stem pith of banana… Ukrainian Food Journal  2021 10.24263-2304-974X-2021-10-1-11
  32. N. S. Rajendran and B.S. Harikumaran Thampi. Pectin—Extraction from underground stem of banana and its structural, rheological, and textural analyses and grading Journal of Food processing and technology 2021 https://doi.org/10.1111/jfpp.15332
  33. Smitha Renganathan, Radhakrishna Gopala Pillai Preliminary analysis of phytochemicals and in vitro free radical scavenging activity of Dhanwantaram Kashayam Adv Biotechnol Exp Ther 2021 https://doi.org/10.5455/jabet.2021.d110
  34. Rasiya K.T, Denoj Sebastian Iturin and surfactin from the endophyte Bacillus amyloliquefaciens strain RKEA3 exhibits antagonism against Staphylococcus aureus Biocatalysis and Agricultural Biotechnology 2021 https://doi.org/10.1016/j.bcab.2021.102125
  35. Ambili M, Denoj Sebastian Evaluation of Sensitivity and Cost-Effectiveness of Molecular Methods for the Co-detection of Waterborne Pathogens in India Evaluation of sensitivity and cost effectiveness of molecular methods for the co-detection of waterborne pathogens in India 2021 https://doi.org/10.1007/s10126-021-10078-9
  36. Sajil K.K. and Gayathri Devi. D. Study on Antioxidant Activity of Ipomoea sepiaria Koenig Ex. Roxb. and Evolvulus alsinoide Linn. by DPPH, FRAP and ABTS Methods. Science, Technology and Development 2020
  37. S Renganathan, RG Pillai, Anti oxidant activities of Dhanwantaram Kashayam –an Ayurvedic polyherbal formulation alleviates diabetic complications in rats, J Diab and Metab disorders. 2020 10.1007/s40200-020-00655-5
  38. "RGPillai Antiproliferative actions of Ziziphus jujube fruit extract is mediated through alterations in Bcl2-Bax ration and through the activation of caspases. Chem Biol Let, 2020 "
  39. Sreena C.P., Denoj Sebastian Arecanut husk: A potential feedstock for enhanced production of endoglucanase by Bacillus subtilis MU S1. Environmental Technology & Innovation. 2020  https://doi.org/10.1016/j.eti.2020.100989
  40. S Renganathan, AS Srivastava, RG Pillai Dhanwantharam kashayam, an Ayurvedic Polyherbal Formulation, Reduces Oxidative Radicals and Reverts Lipids Profile towards Normal in Diabetic Rats Biochemistry and biophysics reports 2020 https://doi.org/10.1016/j.bbrep.2020.100755
  41. Merin Rinky K., Jiji R and Gayathri Devi. D. Garcinia cambogia L. seeds as a source of oil and a trypsin inhibitory protein having microbicidal and antioxidant potentials. Science, Technology and Development 2020
  42. Chithra Pillai, K.V. Faseela and Harikumaran Thampi. Nutritional composition of selected traditional rice varieties of Kerala Journal of Tropical Agriculture 2020
  43. Liji. P and B. S. Harikumaran Thampi. Invitro evaluation of apoptotic induction of butyric acid derivatives in colorectal carcinoma cells. Anticancer research. 2019 http://10.21873/anticanres.13528
  44. Ambili M and Denoj Sebastian. Assessment of bacteriological quality of drinking water from North Kerala, India. Biosci. Biotech. Res. Comm. 12(2) 2019 http://dx.doi.org/10.21786/bbrc/12.2/5
  45. Rinju R and B S Harikumaran Thampi Characterization studies on starch extracted from the. stem of pineapple plant (Ananas comosus) at different. growth stages. Environmental Communication. Biosci. Biotech. Res. Comm. 2019 http://10.21786/bbrc/12.3/37
  46. MC Sereena, D Sebastian. Cloning, expression and characterization of the anticancer protein azurin from an indigenous strain Pseudomonas aeruginosa SSj". International Journal of Peptide Research and Therapeutics. 2019 https://doi.org/10.1007/s10989-019-09924-1
  47. Sabu V…….RG Pillai, Combinatorial Action of Triterpenoid, Flavonoid, and Alkaloid on Inflammation Natural Product Communications 2019 https://doi.org/10.1177/1934578X19868877
  48. MC Sereena, D Sebastian. Evaluation of Anticancer and Anti-hemolytic Activity of Azurin, a Novel Bacterial Protein from Pseudomonas aeruginosa Ssj. International Journal of Peptide Research and Therapeutics 2019 https://doi.org/10.1007/s10989-019-09851-1.
  49. N. S. Rajendran and B.S. Harikumaran Thampi. Extraction and characterisation of pectin from Banana peel. Carpathian  Journal of food science and technology.  2019 https://doi.org/10.34302/2019.11.4.4
  50. Sreena C.P., Denoj Sebastian. Jackfruit outer rind: A sustainable feedstock for fermentable sugar production using recombinant endoglucanase from Bacillus subtilis MU S1. Environmental Technology & Innovation. 2019 https://doi.org/10.1016/j.eti.2019.100448
  51. I C Renu and B S Harikumaran Thampi. Studies on Collagen Hydrolysis by Pineapple (Ananas Comosus) Stem Bromelain. International Journal of Pharmacy and Biological Sciences. 2019
  52. C.P.Sreena, Denoj Sebastian. Augmented cellulase production by Bacillus subtilis strain MU S1 using different statistical experimental designs. Journal of Genetic Engineering and Biotechnology 2018 https://doi.org/10.1016/j.jgeb.2017.12.005
  53. B Kavuthodi, D Sebastian Biotechnological valorization of pineapple stem for pectinase production by Bacillus subtilis BKDS1: Media formulation and statistical optimization for submerged fermentation. Biocatalysis and agricultural biotechnology. 2018 https://doi.org/10.1016/j.bcab.2018.05.003.
  54. Sereena .M.C, Denoj Sebastian. Characterization of anticancer compound azurin from indigenous isolate Pseudomonas aeruginosa Ssj. International Journal of Life Sciences Research. 2018
  55. Emmanuel Simon, Aswini Poyyakkara, Sameer Kumar and Gokuldas Mankadath. Curcumin and its synthetic analogue dimethoxycurcumin differentially modulates antioxidant status of normal human peripheral blood mononuclear cells. Free Radical Research 2018 https://doi.org/10.1080/10715762.2018.1455002
  56. P.G. Sreejesh and E. Sreekumaran. Effect of monosodium glutamate on striato-hippocampal acetylcholinesterase level in the brain of male Wistar albino rats and its implications on learning and memory during aging. , Bioscience Biotechnology Research Communications 2018 http://dx.doi.org/10.21786/bbrc/11.1/11
  57. Bijesh Kavuthodi, Denoj Sebastian. Response Surface Methodological Approach to Optimize the Critical Medium Components for Augmented Pectinase Production by Bacillus subtilis BKDS1. Journal of Pure and Applied Microbiology 2018 http://dx.doi.org/10.22207/JPAM.12.2.62
  58. Bijesh Kavuthodi and Denoj Sebastian. Review on bacterial production of alkaline pectinase with special emphasis on Bacillus species. Microbiological Communication. Biosci. Biotech. Res. Comm. 2018 http://dx.doi.org/10.21786/bbrc/11.1/4
  59. Seena T. Pandarekandy, P. G. Sreejesh, B. S. Harikumaran thampi and E. Sreekumaran. Hypoglycaemic Effect of Glibenclamide: A Critical Study on the Basis of Creatinine and Lipid Peroxidation Status of Streptozotocin-induced Diabetic Rat. Indian Journal of Pharmaceutical Sciences 2017 10.4172/pharmaceutical-sciences.1000290
  60. M.S. Soumya, Gayathri Devi. D, K.M. Shafeekh, Suresh Das and Annie Abraham. Photodynamic therapeutic efficacy of symmetrical diiodinated squaraine in in vivo skin cancer models.   Photodiagnosis and Photodynamic Therapy 2017 10.1016/j.pdpdt.2017.03.009
  61. Shaheedha, Sreena C P, Denoj Sebastian. Poultry Feeds as Carriers of Antibiotic Resistant Enterobacteriaceae. Int J Pharma Res Health Sci. 2017 http://dx.doi.org/ 10.21276/ijprhs.2017.06.10
  62. Greeshma C, Varun, Sreekumaran E. Supplementation of zinc induces retinoic acid-mediated differentiation of rat bone marrow mesenchymal stem cells (MSCS) into insulin producing cells (ipcs) in-vitro. International Journal of Research in Ayurveda and Pharmacy. 2017 10.7897/2277-4343.08150
  63. Panavalappil Greeshma, Korattuvalappil S. Ravikumar , Mangalathmelathil N. Neethu, Meera Pandey,  Karattuthodi Fathimathu Zuhara, Kainoor K. Janardhanan Antioxidant Anti-inflammatory and Antitumor activities of cultured mycelia and fruiting bodies of an edible mushroom, Hypsizygus ulmarius (Bull.:Fr.) International journal of Medicinal Mushrooms. 2016 10.1615/IntJMedMushrooms.v18.i3.60
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